Intracellular Ion Channels regulate many key cellular functions by controlling the ion flux across different intracellular compartments. Our laboratory is particularly interested in ion channles normally found in membranes of the sarcoplasmic/endoplasmic reticulum. We are currently investigating how the calcium release channel (Ryanodine Receptor, RyR2) from the sarcoplasmic reticulum of cardiac myocytes is regulated by calcium content in the lumenal side of the channel.
Other questions qe want to solve is How cytochrome c normally inside the mitochondria is released to the cytosol initiating the apoptotic death of the cell. We think that Bax, a pro-apoptotic member of the Bcl-2 family, forms a pore through which cytochrome c molecules permeate out of the mitochondria.
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